Orthogonal approach to integrate independent omic data

Abstract

Methods and devices for integrating a plurality of data types are provided. The methods include obtaining, via a processor, a plurality of datasets of a given type including measurements of one or more quantitative variables related to a phenotype comparison, and a plurality of datasets of a different type including measurements of one or more quantitative variables related to the same phenotype comparison; calculating, via the processor, effect sizes of the variables of the first type, effect sizes of the variables of the second type, and global p-values for the first and second data types; and combining, via the processor, the effect sizes and/or the global p-values to identify the variables of either type that are relevant in the given phenotype comparison. # Summary. An optional shortened abstract.

Publication
US patent